MolecularCharacteristicsAesthetic Uses
| POLYDEOXYRIBONUCLEOTIDE ( PDRN. PN ) |
| Structure |
|
DEOXYRIBONUCLEOTIDE
 
|
 |
 |
| Molecular Identity |
Deoxyribonucleotide Triphosphates (Avg. MW = 487.0 Da)
dATP = 491.2 Da , 259nm
dCTP = 467.2 Da, 271nm
dGTP = 507.2 Da, 253nm
dTTP = 482.2 Da, 267nm
Ribonucleotide Triphosphates
(Avg. MW = 499.5)
|
Polydeoxyribonucleotides
(Avg.MW =200k Da)
Low Molecular PDRN : ~50k Da
Medium Molecular PDRN : 50k ~1,500k Da
High Molecular PDRN : 1,500k Da~
( Salmon Sperm 50k~1,500k Da,
Porcine Intestine 16k~20k Da )
Polynucleotides (20k Da~2000k Da)
|
1. DNA itself
2. Function : Raw Materials of DNA for Cell Proliferation, Mitochondrial Biogenesis, Regulation of MITF , Angiogenesis
3. Medical Use : Articular Injection to Osteoarthritis, Pressure Sore, Wound Healing, Skin Graft, Skin Plasty, Filler Necrosis, etc.
4. Cosmetic Use: Anti Wrinkle, Elastic , Dermis Volume , Whitening, Smoothing and Skin Texture Improvement.
5. Degradation : Mainly Ribonucleases and others |
| Sodium DNA |
1. Moisturizing : Angiogenesis by increasing VEGF
2. Volume Effect : A2 Receptor Stimulation -> Stem cell(Fibroblast)-> Collagen Synthesis.
3. Wound Healing and Filler Necrosis: Salvage Pathway DNA Replication
4. Whitening : Directly significantly reducing the cellular melanin content in B16-F10 Melanocytes by inhibition of Tyrosinase and Downregulating MITF expression.
5. Soothing : Anti-inflammation and Anti-Ischemic Effect.
6. Skin Texture and Tension : Increase Metabolites by Increasing Mitochodria density in Fibroblast and Suppressing the Elastase Activity.https://link.springer.com/article/10.1007%2Fs12010-019-03171-2 |
