HYALURONIC ACID
MolecularCharacteristicsCross-LinkAesthetic UsesSkin Permeability
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| Molecular Identity |
Single : C14H21NO11: 379Da
Polymer : (C14H21NO11)n : ~7MDa
Average MW : 3~4M Da |
Low Molecular HA : ~500k Da
Medium Molecular HA : 500k ~1,000k Da
High Molecular HA : 1,000k Da~ |
| Characteristics |
1. Components of Human Body esp Skin, Joint, Bone
2. Function : Wound Repair. Tissue granulation, Cell Migration, Skin Healing
3. Medical Use : Articular Injection to Osteoarthritis, Eye Drop to Dry Eye and Eye surgery, Prevent Metastasis of Malignant Cancer, Dermal Filler.
4. Cosmetic Use: Moisturizing, Volume , Tension, Smoothing Skin Texture.
5. Degradation : Main by Hyaluronidase. And Hydrolysis,Ultrasound, Oxidants,Thermal. |
| Sodium Hyaluronate |
MF: C28H44N2NaO23+ MW: 799.6 Da
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1. Moisturizing : Water Bridge Formation between Water Molecule to HA by Anionic Charge.
2. Volume Effect : Synthesis Extracellular Skin Matrix Molecules
3. Tension : Epidermal cell interactions with the surrounding environment
4. Soothing : Anti-inflammation and the Angiogenesis process
저분자 HA의 경우 표피를 투과하여 보습, 소염, 진피의 기질형성, 콜라겐 합성 유도 등의 용도.
고분자 HA의 경우 각질 층 외부에서 보습, 장력, 피부톤 개선 등의 용도
**** Mesotherpy로 고분자 HA를 진피에 전달하는 경우에는 고분자 HA 효과를 진피에서 볼 수 있다.( SKIN BOOSTER ) ****
*** HA Dermal Filler: 697k~1,058kDa, G’ 137Pa~177Pa( Cross Linked HA : 211 ~ 420 Pa), Mixture of Cross-Linked and Noncrosslinked HA,(Restylene Skin Booster) |
| Skin Permeability |
Low Molecular HA : ~500k Da : Can pass Stratum Cornea(~300k Da).
Medium Molecular HA : 500k Da ~1,000k Da : Hard to pass Stratum Cornea.
High Molecular HA : 1,000k Da~ : Very Hard to Pass Stratum Cornea.
DATA Analysis of Topical Apply 0.2% Sodium HA to Artificial Skin
1k Da HA Permeability for 12hrs: 87%
10k Da HA Permeability for 12hrs: 75%
50k Da HA Permeability for 12hrs: 76% ( 가장 함염효과가 높음 )
100k Da HA Permeability for 12hrs: 55% (size : 250nm)
1,500k Da HA Permeability for 12hrs : Lower than 2% ( 콜라겐 합성 효과가 높음)
Reference
1. Effects of Molecular Weights of Sodium Hyaluronate on the Collagen Synthesis, Anti-inflammation and Transdermal Absorption .Department of Biothechnology, The Catholic University of Korea,(Received July 18, 2016; Revised August 15, 2016; Accepted August 31, 2016)
2. Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. https://pubmed.ncbi.nlm.nih.gov/25877232/
3. Effect of High, Medium, and Low Molecular Weight Hyaluronan on Inflammation and Oxidative Stress in an In Vitro Model of Human Nasal Epithelial Cells https://www.hindawi.com/journals/mi/2016/8727289/ |
