WHITENING
A. GENERAL INFO. of SKIN PIGMENTATION
1. How skin color is determined
2. Melanin and melanocyte in a skin tissue
- 멜라닌 세포는 표피층의 기저층에 10% 정도의 비율로 존재한다.
- 인종에 따라 멜라닌 세포수가 다른 것이 아니라 활성도가 다르다.
- 멜라닌 세포에서 멜라닌 색소는 표피 쪽으로만 가지를 뻗어 뿌려준다,
- 표피 기저층을 통과하여 멜라닌 색소가 진피로 내려가는 경우에 진피성 색소침착이 생기고 이의 대표적인 경우가 기미이다.
- Melanocyte takes up about 10% of basal layer on epidermis
- The color of the skin is not determined by the quantity of the number of melanocyte, rather determined by the activation level of melanocyte.
- Melanocyte produces and spreads melanin towards the Keratinocytes by Dendrites.
- Uneven pigmentation occurs when melanin goes down to dermis layer. Freckles are the most common example of uneven pigmentation.
- Melanin is reducing ROS and increasing repair of DNA damage
3. Melanin and Melanocyte 멜라닌 세포와 멜라닌
4. The Formation, Types, Regulation of Melanin Pigments. 멜라닌 색소 합성과정과 멜라닌의 종류
- 유멜라닌(Eumelanin): 올리고머 (oligomer)들의 결합체로 2가지 종류가 있는데 하나는 갈색 멜라닌이고 하나는 갈색보다 어두운 색을 가진 흑색 멜라닌이다.
- 페오멜라닌(Pheomelanin): 분홍 내지는 붉은 빛을 띄는 멜라닌으로 잎술.유두.성기에 주로 분포한다.
- Trichochromes: 붉은 색깔 머리에 주로 분포하는 저 폴리머 멜라닌.붉은 색을 띤다.
- Neuromelanin: 뇌의 신경말단에서 분비되는 멜라닌
- 타이로신 (Tyrosine.): 멜라닌색소의 원재료로 멜라닌 세포에서 일련의 효소 반응에 의해 멜라닌 색소로 합성된다. 인체에서 신경전달물질,호르몬.멜라닌 색소의 원재료인다. 의학적으로는 항우울제, 저혈압 저체온증 치료제, 식욕억제제, 체지방 감소제 등으로 사용된다.
- 글루타치온 (Glutathione): 멜라닌 합성과정에서 갈색 검은색 멜라닌과 경쟁적으로 분홍색 멜라닌 합성을 유도한다. 글루타치온이 많으면 분홍색 멜라닌 합성이 많아져 미백효과를 낸다. 의학적으로는 가장 강력한 항산화제 항암제로 쓰인다. 일명 백옥주사이다.
- Eumelanin: It is a composition of Oligomers and it has 2 types. One is brown melanin and the other is Black melanin
- Pheomelanin: It imparts a pink to red hue depending on the concentration. Usually present in lips, nipples and reproductive organs
- Trichochromes: They have low molecular weight, Usually present in hair and has reddish hue
- Neuromelanin: It is a melanin distributed from the nerve terminal.
- Tyrosine: Tyrosine helps produce melanin. It is the raw ingredient of hormones and melanin. For medical purposes, it is used as antidepressant, medication for hypothermia and hypotension, appetite suppressant and to reduce body fat.
- Glutathione: It induces pink melanin. As it induces the production of pink melanin, it gives whitening effect. For medical purposes, it is used as a strong antioxidant and anti-cancer agent. It is popularly known as 백옥 주사.
5. Causes of Hyperpigmentation 색소 침착의 원인
Sun damage, Inflammations, Skin injuries and Diseases.
ex) Melasma Causes of Chloasma :
기미의 원인
멜라닌의 과생산과 멜라닌이 표피층의 기저세포 층을 통과하여 진피층 까지 축척된 상태를 일으키는 여러원인
1. 자외선 노출-DNA를 파괴하면서 생성된 pro-opiomelanocortin (POMC)가 a-MSH 생산을 늘려 멜라닌을 생산하고 이때 피부기저층의 세포가 파괴되어 방어막이 손실되어 멜라닌이 진피로 이동한다.
2. 호르몬 :여성호르몬(Estradiol)- Thyosine Kinase를 활성화한다.
3. 손상.자국. 노화에 의한 표피 기저층의 손상에 의한 메라닌 이동.
4. 약물. 화장품
5. 질환: 갑상선 호르몬 항진증 . ACTH과분비 질환. Cortisol 과분비 질환.
: Addison Ds- ACTH 생산요구가 melanocyte stimulating hormone (MSH)의 전구물질인 pro-opiomelanocortin (POMC)를 더 생산하게 한다.
6.유전. 가족력
Ultraviolet raddiation;
1) UVR increases proliferation and/or recruitment of melanocytes, the number of dendrites, and the transfer of melanosomes to a supranuclear location on the keratinocytes for DNA photoprotection. – Immediate pigmentation, which appears 5-10 minutes after exposure to UVR, disappears minutes or days later, is largely due to UVA, and is not dependent on increased melanin synthesis, but on the oxidation of pre-existing melanin and redistribution of melanosomes to the epidermal upper layers.
2)The expression of POMC peptides, MC1-R, and melanogenic enzymes increases in keratinocytes and melanocytes respectively. – Delayed pigmentation, which occurs 3-4 days after exposure to UVR, disappears within weeks, is due to UVA and mainly UVB radiation, and results from an increased level of epidermal melanin, particularly eumelanin, providing photoprotection.
B. SKIN WHITENING METHODS
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Mechanism of Whitening 주요 미백 메카니즘
2. Main whitening agents and their mechanism 주요 미백 물질과 작용점
3. The Summary of Main whitening agents
Major Triple Treatment to Melasma
Hydroquinone + Retinoids + Topical steroids
Category I
Inhibition or Acceleration to Transcription
TGF-b
Down-regulate activity of microphthalmia-associated transcription factor (MITF) which is is a basic helix-loop-helix leucine zipper transcription factor that regulates melanocyte cellular differentiation as well as the transcription of melanogenic enzymes (tyrosinase, TYRP1 and TYRP2) and melanosome structural proteins (MART-1 and PMEL17). TGF-β , via inhibition of the cAMP pathway, and GLI2 inhibit MITF transcription via separate cis-elements.
EGF(Epidermal Growth Factors)
Epidermal Cell Ratio will increase by EGF, Because Melanocyte has no EGF Receptor.
N-acetyl glucosamine
It inhibits the glycosylation of tyrosinase.
Category II
Inhibition to Melanogenesis .Tyrosinase
Hydroquinone :
1) Inhibition of the enzyme, tyrosinase. HQ affects not only the formation, melanization, and degradation of melanosomes,
2) but it also affects the membranous structures of melanocytes and
3)eventually causes necrosis of whole melanocytes by DNA Damage of Melanocyte.
Tranexamic Acid
It is a composition of Plasmin and plasminogen which suppresses activation of melanocytes and formation of prostaglandin. Eventually it suppresses the formation of melanin. It is the safest whitening agent.
Arbutin
Arbutin acts by the inhibition of tyrosinase, thereby decreasing melanin formation.The action of arbutin is dose-dependent and less toxic than hydroquinone. Deoxyarbutin is a recently developed derivative of arbutin that has been produced by removing the hydroxyl groups from the molecule. This produces reversible skin-lightening by direct inhibition of tyrosinase.
Topical steroids
The inhibitory effects of corticosteroids on the synthesis of mediators like prostaglandin and leukotriene may effects on melanogenesis.
Oleic acid , Linoleic acid, α-Linolenic acid
Suppresses melanogenesis by Ubiquitin-Dependent Proteolysis of tyrosinase.
Ascorbic acid
Ascorbic acid 1) reduces DOPAquinone to DOPA and preventing free-radical production and absorption of ultraviolet radiation and 2) increases keratinocyte deferenciation 3) Collagenesis 4) Repair DNA damage by UV Damage. 5) decreases inflammation.
Glabridin
That have tyrosinase inhibitory as well as anti-inflammatory properties in experimental studies.
Azelaic acid
Azelaic acid competitively inhibits tyrosinase.
Kojic acid
It acts by inhibiting the production of free tyrosinase; it is also a potent antioxidant.
Mequinol
Its mechanism of action is unclear; however, being a substrate of tyrosinase, it may act as a competitive inhibitor of the formation of melanin precursors.
N-acetyl-4-S-cysteaminylphenol
NCAP is a phenolic agent which acts as an alternative substrate for tyrosinase, thus inhibiting the enzyme’s activity.
Soybean extracts, Ellagic acid, Resveratrol, Oxyresvaretral
Category III
Acceleration of Epidermal Turnover
Retinoids
Retinoids affect multiple steps in the melanization pathway. Tretinoin promotes the rapid loss of pigment through epidermopoiesis and increased epidermal turnover decreases the contact time between keratinocytes and melanocytes. Retinoic acid (RA) suppresses UVB-induced pigmentation by reducing tyrosinase activity. The acid acts at a posttranscriptional level on tyrosinase and tyrosinase-related protein.
AHAs(a-hyroxy Acids)
The mechanism of its effect might be due to epidermal remodeling and accelerated desquamation specially to St.Coneum, which would result in quick pigment dispersion on pigmentary lesions. It also directly reduces melanin formation in melanocytes by tyrosinase inhibition. But They can increase photosensitivity, so have not expose to UV Linght after AHAs Procedure.
They are Glycolic acid (from sugar cane), Lactic acid (from sour milk), Malic acid (from apples),Citric acid (from citrus fruits) and Tartaric acid (from grape wine).
Ascorbic acid
Ascorbic acid 1) reduces dopaquinone to DOPA and preventing free-radical production and absorption of ultraviolet radiation and 2) Keratolytic effect.
BHA(b-hyroxy Acids)
Salicylic acid
Vitamin C, vitamin E, thioctic acid, retinoids, lactic acid, glycolic acid, salicylic acid, liquiritin
Category IV
Sunscreen Agents
Alpha-tocopherol
It is UV-absorbance spectrum (lambda max 295 nm) extends well into the solar spectrum and have significant effect in the retardation of melanogenesis, possibly by inhibiting tyrosine hydroxylase activity . Also It accelerate Epidermal Turn Overate.
Phytoene , Phytofluene, Lycopene
The substances in tomatoes directly absorb UV rays, inhibiting the UV rays to reach melanocytes.
PHYSICAL UV PROTECTION:
Titanium dioxide (UVA,UVB ), Zinc oxide (UVA), Iron Oxide, kaolin, talc, calcium carbonate, and magnesium oxide. and more
CHEMICAL UV PROTECTION:
Bemotrizinol, Avobenzone, bisoctizole, benzophenone-3 (BZ-3, oxybenzone), and octocrylene and more.
ORGANIC UV PROTECTION
Ecamsule (terephthalylidene dicamphor sulphonic acid), dometrizole trisiloxane, bemotrizinol, bisoctrizole and more
Category V
Alternative method , Anti-inflammation or Still under investigation
Glutathione, L-Cystein
Competitive inhibit Eumelanin (Brown, Black Color Melanin) by Augmentation to Pheomelanin(Yellow,Pink, Blonde Color Melanin) synthesis.
Niacinamide
It prevent the transfer of melanin and melanosomes from melanocytes to the keratinocytes.
Steroids
It is strong Anti-inflammatory Medicine.
Flavonoids
Many plant-derived flavonoid compounds have hypopigmentary effects and their roles are still under investigation. These include catechin conjugated with gallic acid (from green tea leaves), ellagic acid (from green tea, strawberry, eucalyptus etc), and aloesin(from aloe tree).Other agents known to affect melanin pigmentation and sometimes used in formulations are N-acetyl glucosamine, thiotic acid (alpha-lipoic acid), gentisic acid, soybean extract, and paper mulberry extract.
4. Understanding the Main Ingredients of Meensarang Whitening Solution.
1. Tranexamic Acid
It is a composition of Plasmin and plasminogen which suppresses activation of melanocytes and formation of prostaglandin. Eventually it suppresses the formation of melanin. It is the safest whitening agent. Usually orally consumed or injected.
a-MSH을 촉진 하는 플라스민이나 플라스미노겐에 결합하여 티로시나제 활성을 억제하고 프로스타글란딘 분비를 억제하여 멜라닌 합성을 억제. 안전한 최고의 미백치료제. 피부과에서 먹는 약이나 주사로 직접 주입하기도 한다.
Two Melanin Pigment Inhibiting Mechanisms of Tranexamic Acid(TXA)
2. Arbutin
티로시나제의 활성을 억제하여 멜라닌의 생합성 과정 전반에 관여하여 미백효능을 줍니다. 백피증 유발과 발암성분인 하이드로퀴닌을 대신한 미백 물질이다
3. a-Bisabolol
브라질의 청정 아마존 열대우림 지역에 서식하는 칸데이아 나무(Eremanthus Erythropappus) 에서 추출한 천연 α-bisabolol 성분으로 멜라닌 세포 내에서 Adenyl Cyclase 가 C-AMP를 활성화 시키는 과정을 차단해서 멜라닌 합성을 차단한다. 알파 비사보놀은 멜라닌 세포 내에서 Adenyl Cyclase 효소와 결합하여 c-AMP 생성을 억제함으로서 멜라닌 색소의 합성을 유도는 유전자 코드인 MITF(Microphthalmia-associated transcription factor)을 억제한다.
4. Niacinamide (Vit .B3)
It helps maintaining white and clear skin as it decreases the transfer of melanin pigment from melanocyte to keratinocyte.
- Increases skin ceramide and fatty acid levels. Dry, rough skin lacks ceramide. When 2% of niacinamide is applied to the skin for 4 weeks, ceramide of skin dermal layer increased by 34% and fatty acid increases by 67%.
- It prevents loss of skin moisture and stimulate the microcirculation of the dermis.
- Improves skin pigmentation and inhibits transmission of melanosome.
- Promotes collagen secretion to prevent skin aging and improve elasticity.
- Reduce sebum and improve skin trouble.
- When used together with vitamin C, the activity of vitamin C is increased as Niacin amide stabilizes Vitamin .
멜라노사이트에서 케라티노사이트로의 멜라닌의 이동을 감소시켜 깨끗한 피부를 유지시킨다.
1. 피부의 세라마이드와 지방산 레벨의 증가. 건조하고 거친 피부는 세라마이드가 부족하다. 나이아신아마이드 2%를 4주간 처방하였을 때 피부 진피층의 세라마이드 34%증가, 지방산 67%증가 효과를 보인다.
2. 피부 수분 손실을 막을 수 있었으며, 진피의 미세순환을 자극.
3. 피부 착색 개선 및 멜라노좀 전이 억제.
4. 콜라겐 분비를 촉진하여 피부노화 개선 및 탄력성을 증가.
5. 피지 억제 및 지성트러블 개선
6. 비타민C 를 안정화시켜 비타민C와 함께 사용하면 비타민 C의 활성이 증가된다.
5. Vit C
From the formation process of melanin, it revivifies the L-DOPA -> DOPA quinone process to DOPA quinone-> L-DOPA. G. thus, it suppresses the formation of melanin and protects the skin from absorbing UV rays . It also protects the skin from oxidation of basal cells and helps recovery. However, as a cosmetic ingredient, it is easily oxidized, thus often orally consumed or taken while in Magnesium Ascorbyl Phosphate(MAP) state or applied with Iontophoresis.
멜라닌 합성 진행 과정의 L-DOPA -> DOPA quinone과정을 DOPA quinone-> L-DOPA 역순으로 환원시켜버려 멜라닌 합성을 저해하고 각질층의 맨 윗층에서 자외선의 흡수를 차단하며 기저세포의 산화를 막아 파괴를 막고 재생시킨다. 그러나 화장품 원료로서는 너무 쉽게 산화되어 복용하거나 Magnesium Ascorbyl Phosphate 상태로 사용하거나 이온토를 이용해 흡수 시킨다.
6. 녹차(백차) 추출물 Green tea (white tea) extract
Codecin has been widely used in cosmetics for anti-aging, whitening, soothing and cleansing – As it also has UV protection effect, anti-bacterial and antioxidant effect, it helps reduce skin trouble and it is very effective in preventing fine wrinkles and maintaining healthy skin.
녹차의 지표 성분 카데킨은 노화억제, 피부미백, 피부진정 및피부를 맑고 깨끗하게 가꾸어 주는 효능으로 오래전부터 차와 미용용품 등에 다양하게 활용되고 있다 .– 자외선 차단의 효과와 항균, 항염, 항산화효과로 피부트러블을 감소시켜 주며,피부의 잔주름 예방과 건강한 피부를 유지하는데 매우 효과적이다.
– 폴리페놀 : 항산화 효과로 노화예방에 효과적
– 카데킨 : 독소와 노페물 배출로 피부를 맑게
– 비타민C : 멜라닌 색소 침착을 막아 미백에 효과
– 비타민B : 여드름과 민감성 트러블 진정
그 외 딥클징 효과로 피지, 각질제거에 뛰어나며 피부 재생 도와 피부노화와 건조를 막는다.
7. 감초추출물 (Glabridin)
* Ingredients
Apigenin, Ascorbic acid, Beta carotene, Beta sitosterol, Camphor, Glabridin, Glycyrrhetic acid, Glycyrrhetinic acid, Glycyrrhizic acid, Glycyrrhizin, Liquirtin, Selenium, Umbelliferone
* Main function 주요기능
skin calming and soothing, treatment of allergies, anti-inflammation, anti-oxidation, skin tumor prevention, hyaluronic acid decomposition enzyme inhibition, anti-aging, antibacterial, heavy metal detoxification, anti-inflammation, acne prevention, whitening, immunity stimulation, dandruff prevention, VEGF suppression, sunscreen.
피부진정, 항알러지, 항균, 항산화, 피부종양방지, 히아루론산분해효소억제, 노화방지, 항균, 중금속해독,항염, 여드름방지, 미백, 면역촉진, 비듬방지, VEGF억제, 썬스크린 등의 효과.
* Whitening effect of licorice 감초의 미백 효과
Glabridin, the main constituent of licorice extract, has an anti – inflammatory action of the skin and inhibits the melanin synthesis. Thus gives whitening effect. Glycyrrhizinic acid and Glychrrhetinic acid are also known to have anti-inflammatory effects.
감초 추출물의 주 구성 성분인 Glabridin은 피부에 대한 항염작용과 Tyrosinase 억제로 인한 미백작용 멜라닌 합성을 억제한다.
Glycyrrhizinic acid, Glychrrhetinic acid 또한 항염효과가 있는것으로 알려져 있다.
8. Crocodile Oil 악어오일 정제유(oleic acid , linoleic acid , α-linolenic acid)
1) It forsters the Proteolysis of tyrosinease, which is the main enzyme in melanin synthesis. Thus, preventing the formation of melanin pigment. Crocodile oil contains 54% of the constituents of oleic acid (Omega-9), linoleic acid (Omega-6) and α-linolenic acid (Omega-3) which are the main constituents of this mechanism of inhibiting melanin synthesis
2) Crocodile oil regenerates damaged cells, especially the damages from ultraviolet light, by rapidly increasing the TGF b concentration in dermal tissues.
3) Crocodile oil is excellent for removal and prevention of recurrence of age spot.
Our clinic uses crocodile oil extracted with maximized the linoleic acid, linoleic acid, oleic acid to more than 80% and excluded palmitic acid, stearic acid and arachidonic acid which induce melanin synthesis.
1) 멜라닌색소 합성 주요 효소인 타이로신나제를 단백 분해 하여 멜라닌 색소가 만들어지지 않게 한다. 악어오일은 이 메카니즘의 주요 성분인 oleic acid(Omega-9) , linoleic acid(Omega-6) , α-linolenic acid(Omega-3) 의 조성성분이 54%나 함유되어 있고 있어 멜라닌 색소 합성을 저해하고, 2) 악어오일이 진피 조직내의 TGF b 농도를 급속히 상승시키는 효과로 특히 자외선으로부터 손상된 세포를 재생하는 반면 3) 세포 재생 말기에 TGF-b1. SMAD 3 에 의한 상피세포와 진피세포의 과다 증식 억제에 의한 멜라닌 합성을 유도하는 MITF 억제효과.
이러한 기전은 특히 자외선에 의한 Sunburn유발 색소침착과 상처에 의한 색소침착, PIH에 최고의 효과를 보이며, 이미 형성된 착색,이상 형성된 조직을 새로운 정상적인 세포로 대치하여 광선 각화증 (검버섯)의 제거와 재발 방지에 탁월하다.
본원은 멜라닌색소 생산을 활성 시키는 팔믹산.스테아릭산,아라키도닉산을 배제하고 리놀레익산.리놀레닉산.올레익산 의 농도를 80% 이상으로 최대한 늘린 추출 정제 악어오일을 사용했다.
악어오일의 조직 재생 능력
악어오일의 TGF-b1. SMAD 3 에 의한 상피세포와 진피세포의 과다 증식 억제에 의한 멜라닌 합성을 유도하는 MITF 억제효과.
9. Tomato extracts 토마토 추출물(Phytoene , Phytofluene, Lycopene)
The substances in tomatoes directly absorb UV rays, inhibiting the UV rays to reach melanocytes.
자외선을 직접 흡수하여 자외선이 멜라닌 세포에 도달하지 못하게 하는 카로틴 계열의 성분으로 토마토에 가장 많이 포함되 있다.
10. Tocopherol 토코페롤
1) directly inhibits tyrosinase enzyme that synthesizes melanin pigment in melanocytes,
2) decreasing the levels of lipid peroxidation and ROS generation.
3) increases intracellular concentration of glutathione in the cell, thus forming pink Color Pheomelanin pigment.
4) UV-absorbance spectrum (lambda max 295 nm) extends well into the solar spectrum.
11. Aspirin (Salicylic Acid)
12. Ginseng and Ginsenosides
5. Hemoglobin, Carotene the Others Skin Color Agents
Hemoglobin : Oxyhemoglobin color is red color. The primary light absorbers in skin are hemoglobin and melanin. Most of scattering is attributed to collagen fibers and in pigmented skin to melanosomes. Traditionally skin redness is considered to arise due to locally elevated concentrations of hemoglobin, whereas skin pigmentation is attributed to melanin.
b-Carotene: Beta-carotenemia will deposit yellow color at tissue(30 milligrams or more — may cause skin discoloration).
C. Prescript care after Laser treatment 색소 레이저 후 처치 전용 처방화장품
1. Meensarang Whitening Serum 미인사랑 미백 세럼
Main effects
Suppresses the activation of melanin cells
Inhibits Melanin formation.
Inhibits the distribution of melanin to the stratum corneum
Peeling of dead skin cells
Skin recovery
UV protection
주요 효과
1) 멜라닌 세포의 활성 억제
2) 멜라닌 색소 합성억제
3) 멜라닌색소 각질층으로 분비 억제
4) 각질 층의 박피
5) 멜라닌 세포를 제외한 상피 세포 재생
6) 자외선 차단
Usage
- Apply right after the laser treatment.
- Apply every morning and evening, after washing the face.
Apply about 1ml and let it be absorbed before applying makeup.
사용법
1) 레이저 시술 직후 재생크림 도포전에 시술부위에 도포
2) 아침 저녁 세안 후 첫번 째로 얼굴에 1ml 정도 도포 하여 흡수시킨 후 메이크업
3) 자외선 노출 환경에 처할 경우 충분히 2ml정도 노출 부위에 도포한 후 자외선 차단제 도포.
4) 자외선 노출 후 최대한 빠른 시간내에 충분한 양을 부위에 도포
Volume
- Travel size: 7ml silicon cap ampoule container
- Shop size : 30ml serum container
용량
1) 휴대용 : 7ml 실리콘 탭 앰플 용기.
2) 상용 : 30ml 세럼 용기.
Main ingredients
Tranexamic Acid, Arbutin, Niacinamide(VIT B3), allantoin, chamomile extract, licorice extract, white tea extract, honey extract, EGF serum complex
주성분
미백 효과 고용량 조성물:
트라넥삼산, 알부틴, 나이아신 아마이드(VIT B3), 알란토인, 케모마일 추출물, 감초 추출물, 백차 추출물, 꿀 추출물, EGF 세럼 콤플렉스
EGF의 세포재생능력이 멜라닌세포에는 수용체가 없어서 자외선으로부터 손상된 세포의 재생 시 보통피부세포만 재생 분열이 일어나 멜라닌 세포의 상대적 비율이 떨어진다. 자외선에 의한 멜라닌 색소 증가에 탁월하게 효과가 있다. 펩타이드를 인체유래줄기세포성장인자인 RH-만을 사용했다.
INGREDIENTS:
Distilled water, tranexamic acid, arbutin, niacin amide (B3 VIT), Chamomile extract, licorice extract, white tea extract, honey extract, tocopherol. EGF Serum Complex – Buckwheat Extract, Grape Extract, Mung Bean Extract, Barley Leaf Extract, Amaranth Seed Extract, Arbutin, 1,2-Hexanediol Dipropylene Glycol, Glycerin, Betaine, RH-Oligopeptide-1, RH -Polypeptide-1, RH-polypeptide-11, RH-oligopeptide-2, RH-polypeptide-10, RH-polypeptide-28, RH-oligopeptide-9, capper tripeptide- 29, acetyl hexapeptide-8, palmitoyl pentapeptide-4, nicotinoyl tripeptide-1, nicotinoyl dipeptite-22, nicotinoyldipeptide-23, nonapeptide-1, phytosphingosine, lecithin , Lactobacillus / Pomegranate extract, Lactobacillus / Pomegranate extract, Lactobacillus / Red ginseng fermentation filtrate, Lactobacillus / Ginseng extract fermentation filtrate, Lactobacillus / Soybean extract fermentation filtrate, Gakyung extract, Seiho extract, Ginseng extract, Root extract , Jujube extract, liquorice extract, Allantoin, Sodium Hyaluronic Acid, Alligator Extract, Chrysanthemum Extract, Chrysanthemum Extract, Chrysanthemum Extract, Golden Extract, Chrysanthemum Extract, Chrysanthemum Extract, Tooth Extract, Licorice Extract, by Nate, evening primrose oil, tea tree leaf oil, lavender oil, cypress oil, tea seed oil, adenosine, panthenol, alpha-bisabolol, Osaka Ride search by -1, niacinamide.
전성분 :
증류수, 트라넥삼산, 알부틴,나이아신 아마이드(VIT B3), 케모마일 추출물, 감초 추출물, 백차 추출물, 꿀 추출물,토코페롤. EGF 세럼 콤플렉스- 메밀싹추출물 , 밀싹추출물 , 녹두싹추출물, 보리잎추출물, 아마란스씨추출물, 알부틴 , 1,2-헥산디올디프로필렌글라이콜, 글리세린, 베타인, RH-올리고펩타이드-1, RH-폴리펩타이드-1, RH-폴리펩타이드-11, RH-올리고펩타이드-2, RH-폴리펩타이드-10, RH-폴리펩타이드-28 , RH-올리고펩타이드-9 , 카퍼트리펩타이드-1, 트리펩타이드-29,아세칠헥사펩타이드-8 , 팔미토일펜타펩타이드-4, 니코티노일트리펩타이드-1, 니코티노일디펩타이트-22, 니코티노일디 펩타이드-23, 노나펩타이드-1, 피토스핑고신, 레시틴, 토코페릴아세테이트, 락토바실러스/석류발효추출물, 락토바실러스/홍삼발효여과물, 락토바실러스/금은화추출물발효여과물, 락토바실러스/콩추출물발효여과물, 길경추출물, 시호추출물, 인삼추출물, 참마뿌리추출물, 대추추출물, 백출추출물, 연교추출물, 천궁추출물, 더덕추출물, 황금추출물, 형개추출물, 상백피추출물, 치차추출물, 감초추출물, 백지추출물, 금은화추출물, 귤피추출물, 복령추출물, 당귀추출물, 작약추출물, 황기추출물, 알란토인, 소듐하이알루로네이트, 달맞이꽃오일, 티트리잎오일, 라벤더오일, 편백오일, 녹차씨오일, 아데노신, 판테놀, 알파-비사보롤, 바이 오사카라이드검-1, 나이아신아마이드.
2. Meensarang Whitening Cream 미인사랑 미백 크림
Main Effects
- Suppresses the activation of melanin cells
- Inhibits Melanin formation.
- Inhibits the distribution of melanin to the stratum corneum
- Peeling of dead skin cells
- Skin Cell regeneration except Melanocyte.
- UV protection
주요 효과
1) 멜라닌 세포의 활성 억제
2) 멜라닌 색소 합성억제
3) 멜라닌색소 각질층으로 분비 억제
4) 각질 층의 박피
5) 멜라닌 세포를 제외한 상피 세포 및 진피 세포재생
6) 자외선 차단
Usage
- Apply right after the laser treatment.
- Apply evenly as a skin recovery cream every evening
- Use as a skin recovery cream on a damaged skin
- Use right after the exposure under UV rays.
사용법
1) 레이저 시술 직후 재생크림 대신에 시술부위에 도포.
2) 취침전 크림 용도로 얇게 도포.
3) 스크레치 또는 일광화상에의한 피부 손상시 회복용.
4) 자외선 노출 후 최대한 빠른 시간내에 충분한 양을 부위에 도포 .
Volume
- Shop size: 30g cream jar